Summary

Name ABCA3
Full Name Phospholipid-transporting ATPase ABCA3
Synonyms ABC-C transporter, ATP-binding cassette transporter 3, ATP-binding cassette 3 | ABC3
Primary ID Q99758
Links - -
Type protein
Relations 1
Function Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:28887056, PubMed:31473345, PubMed:27177387). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:26903515, PubMed:25817392, PubMed:27177387).

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Relations

Regulator Mechanism target score ℹ
+ SALL4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCA3 0.286
Publications: 1 Organism: Homo Sapiens