3.0
Summary
| Name |  NKX3-1View Modifications |
| Full Name | Homeobox protein Nkx-3.1 |
| Synonyms | Homeobox protein NK-3 homolog A | NKX3.1, NKX3A |
| Primary ID | Q99801 |
| Links |  -  -  |
| Type | protein |
| Relations | 14 |
| Pathways | Prostate Cancer |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates 
phosphorylation
|
NKX3-1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM | down-regulates quantity by destabilization 
phosphorylation
|
NKX3-1 | 0.371 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PTEN | up-regulates quantity by stabilization
dephosphorylation
|
NKX3-1 | 0.455 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | CSNK2A2 | up-regulates
phosphorylation
|
NKX3-1 | 0.321 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | NKX3-1 | down-regulates activity
binding
|
HDAC1 | 0.376 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | NKX3-1 | up-regulates quantity by stabilization 
|
TP53 | 0.364 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | NKX3-1 | form complex 
binding
|
NKX3-1/SRF | 0.405 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Smooth Muscle | |||
| + | AR | up-regulates quantity by expression
transcriptional regulation
|
NKX3-1 | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | NKX3-1 | up-regulates quantity by expression
transcriptional regulation
|
ACTG2 | 0.291 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NKX3-1 | down-regulates quantity by repression
transcriptional regulation
|
AR | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | NKX3-1 | down-regulates activity
|
AKT | 0.503 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | ERG | down-regulates quantity by repression 
transcriptional regulation
|
NKX3-1 | 0.342 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||