Summary

Name HOPX
Full Name Homeodomain-only protein
Synonyms Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1 | HOD, HOP, LAGY, NECC1, OB1
Primary ID Q9BPY8
Links - -
Type protein
Relations 2
Function Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FLG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LORICRIN 0.2
Publications: 1 Organism: Homo Sapiens