Summary

Name VKORC1
Full Name Vitamin K epoxide reductase complex subunit 1
Synonyms Vitamin K1 2,3-epoxide reductase subunit 1 | VKOR
Primary ID Q9BQB6
Links - -
Type protein
Relations 5
Pathways Vitamin-K cycle
Inhibitors warfarin
Function Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.

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Relations

Regulator Mechanism target score ℹ
+ warfarindown-regulates activity img/direct_inhibition.png chemical inhibition VKORC1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Vitamin-K cycle
+ VKORC1down-regulates quantity img/direct_inhibition.png chemical modification vitamin K epoxide 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Vitamin-K cycle
+ VKORC1down-regulates quantity img/direct_inhibition.png chemical modification vitamin K 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Vitamin-K cycle
+ VKORC1up-regulates quantity img/direct-activation.png chemical modification Reduced Vitamin K 0.8
Publications: 2 Organism: Homo Sapiens
Pathways:Vitamin-K cycle