Summary

Name PLCD4
Full Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Synonyms hPLCD4, Phosphoinositide phospholipase C-delta-4, Phospholipase C-delta-4, PLC-delta-4
Primary ID Q9BRC7
Links - -
Type protein
Relations 2
Function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

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Relations

Regulator Mechanism target score ℹ
+ PLCD4up-regulates img/direct-activation.png chemical modification 1D-myo-inositol 1,4,5-trisphosphate 0.8
Publications: 2 Organism: Homo Sapiens