Relation Results

Summary

Name WAC
Full Name WW domain-containing adapter protein with coiled-coil
Synonyms WAC_HUMAN | KIAA1844
Primary ID Q9BTA9
Links - -
Type protein
Relations 5
Function Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA pol ...
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Type: Score: Layout: SPV 
0.20.2CDK1WACPLK1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK1up-regulates activity img/direct-activation.png phosphorylation WAC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265032 Thr244 AETHSSStPVQHPIK Homo sapiens HeLa Cell
pmid sentence
Cyclin-dependent kinase 1 (Cdk1) phosphorylates WAC, priming its direct interaction with the polo-box domain of Plk1. Knockdown of WAC compromises Plk1 activity and delays mitotic entry.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265035 Thr457 YVSPRIStPQTNTVP Homo sapiens HeLa Cell
pmid sentence
Cyclin-dependent kinase 1 (Cdk1) phosphorylates WAC, priming its direct interaction with the polo-box domain of Plk1. Knockdown of WAC compromises Plk1 activity and delays mitotic entry.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265034 Thr471 PIKPLIStPPVSSQP Homo sapiens HeLa Cell
pmid sentence
Cyclin-dependent kinase 1 (Cdk1) phosphorylates WAC, priming its direct interaction with the polo-box domain of Plk1. Knockdown of WAC compromises Plk1 activity and delays mitotic entry.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265033 Thr482 SSQPKVStPVVKQGP Homo sapiens HeLa Cell
pmid sentence
Cyclin-dependent kinase 1 (Cdk1) phosphorylates WAC, priming its direct interaction with the polo-box domain of Plk1. Knockdown of WAC compromises Plk1 activity and delays mitotic entry.
Publications: 4 Organism: Homo Sapiens
+ WACup-regulates activity img/direct-activation.png binding PLK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265036 Homo sapiens HeLa Cell
pmid sentence
Here, we report that the activation of Plk1 requires WAC, a WW domain-containing adaptor protein with a coiled-coil region that predominantly localizes to the nucleus in interphase. Cyclin-dependent kinase 1 (Cdk1) phosphorylates WAC, priming its direct interaction with the polo-box domain of Plk1. 
Publications: 1 Organism: Homo Sapiens
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