| + |
PBX4 | down-regulates quantity by repression 
transcriptional regulation
|
FGF8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265780 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265806 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
PBX4
- 
- 
3.0