Summary

Name NUF2
Full Name Kinetochore protein Nuf2
Synonyms hNuf2, hNuf2R, hsNuf2, Cell division cycle-associated protein 1 | CDCA1, NUF2R
Primary ID Q9BZD4
Links - -
Type protein
Relations 2
Function Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NUF2 0.2
Publications: 1
+ form complex img/form-complex.png binding Ndc80 complex 0.973
Publications: 1