+ |
PRKACA | down-regulates
phosphorylation
|
MCOLN1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-158946 |
Ser557 |
SGKFRRGsGSACSLL |
Homo sapiens |
|
pmid |
sentence |
17988215 |
The stimulatory effect of h89 on mcoln1 function was not observed when ser(557) and ser(559) were mutated to alanine residues, indicating that these two residues are essential for pka-mediated negative regulation of mcoln1. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-158950 |
Ser559 |
KFRRGSGsACSLLCC |
Homo sapiens |
|
pmid |
sentence |
17988215 |
The stimulatory effect of h89 on mcoln1 function was not observed when ser(557) and ser(559) were mutated to alanine residues, indicating that these two residues are essential for pka-mediated negative regulation of mcoln1. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MCOLN1 | up-regulates quantity
relocalization
|
calcium(2+) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255308 |
|
|
Homo sapiens |
|
pmid |
sentence |
26000950 |
Induction of autophagy and lysosomal biogenesis via TFEB required MCOLN1-mediated calcineurin activation, linking lysosomal calcium signaling to both calcineurin regulation and autophagy induction. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FIG4 | up-regulates activity
|
MCOLN1 |
0.367 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253536 |
|
|
Homo sapiens |
|
pmid |
sentence |
23165282 |
PI(3,5)P2 begins to be synthesized on endosomal membranes and is additionally required for the activation of lysosomal TRPML1/MCOLN1 channels. Thus, a deficiency of FIG4/PI(3,5)P2 would impair TRPML1/MCOLN1 channel function, leading to the accumulation of calcium in the lysosomes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |