Summary

Name MAGT1
Full Name Magnesium transporter protein 1
Synonyms MagT1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1, Oligosaccharyl transferase subunit MAGT1, Implantation-associated protein, IAP | IAG2
Primary ID Q9H0U3
Links - -
Type protein
Relations 1
Function Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (PubMed:31831667). Involved in N-glycosylation of STT3B-dependent substrates (PubMed:31831667). Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.

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Relations

Regulator Mechanism target score ℹ
+ MAGT1form complex img/form-complex.png binding OST-B complex 0.691
Publications: 1 Organism: Homo Sapiens