| + |
TGFBR1 |
phosphorylation
|
TP63 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199781 |
Ser160 |
SSTFDALsPSPAIPS |
Homo sapiens |
|
| pmid |
sentence |
| 23166821 |
We show that phosphorylation of _np63_ at s66/68 in response to ultraviolet (uv) irradiation is mediated by alk5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199785 |
Ser68 |
FLEQPICsVQPIDLN |
Homo sapiens |
|
| pmid |
sentence |
| 23166821 |
We show that phosphorylation of _np63_ at s66/68 in response to ultraviolet (uv) irradiation is mediated by alk5 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates quantity by destabilization 
phosphorylation
|
TP63 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277414 |
Ser301 |
S-->T |
in vitro |
|
| pmid |
sentence |
| 30301786 |
P38α phosphorylates and destabilizes p63. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277414 |
Ser310 |
LYNFMCNsSCVGGMN |
in vitro |
|
| pmid |
sentence |
| 30301786 |
P38α phosphorylates and destabilizes p63. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
RPS6KB1 | down-regulates
phosphorylation
|
TP63 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180771 |
Ser477 |
NSMNKLPsVSQLINP |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180775 |
Ser560 |
LARLGCSsCLDYFTT |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180784 |
Thr491 |
PQQRNALtPTTIPDG |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates
phosphorylation
|
TP63 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180759 |
Ser477 |
NSMNKLPsVSQLINP |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180763 |
Ser560 |
LARLGCSsCLDYFTT |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180767 |
Thr491 |
PQQRNALtPTTIPDG |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ATM | down-regulates
phosphorylation
|
TP63 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180747 |
Ser477 |
NSMNKLPsVSQLINP |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180751 |
Ser560 |
LARLGCSsCLDYFTT |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180755 |
Thr491 |
PQQRNALtPTTIPDG |
Homo sapiens |
|
| pmid |
sentence |
| 18769144 |
Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. We found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates quantity by stabilization 
phosphorylation
|
TP63 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260934 |
Tyr149 |
SVTAPSPyAQPSSTF |
Homo sapiens |
|
| pmid |
sentence |
| 19783996 |
In cell lines, upon cisplatin treatment, c-Abl phosphorylates TAp63 on specific tyrosine residues. Such modifications affect p63 stability and induce a p63-dependent activation of proapoptotic promoters. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260932 |
Tyr171 |
AIPSNTDyPGPHSFD |
Homo sapiens |
|
| pmid |
sentence |
| 19783996 |
In cell lines, upon cisplatin treatment, c-Abl phosphorylates TAp63 on specific tyrosine residues. Such modifications affect p63 stability and induce a p63-dependent activation of proapoptotic promoters. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260933 |
Tyr290 |
RQSVLVPyEPPQVGT |
Homo sapiens |
|
| pmid |
sentence |
| 19783996 |
In cell lines, upon cisplatin treatment, c-Abl phosphorylates TAp63 on specific tyrosine residues. Such modifications affect p63 stability and induce a p63-dependent activation of proapoptotic promoters. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CRBN | down-regulates quantity by destabilization
polyubiquitination
|
TP63 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272214 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 31591562 |
CRBN functions as a substrate receptor of the E3 ubiquitin ligase CRL4, whose substrate specificity is modulated by thalidomide and its analogs.When thalidomide binds to CRBN, substrate specificity of CRL4CRBN is altered and CRBN neomorphically binds to ∆Np63, TAp63 and other neosubstrates and ubiquitinates them for proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP63 | up-regulates quantity by expression
transcriptional regulation
|
SUN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263278 |
|
|
Mus musculus |
Epidermal Stem Cell |
| pmid |
sentence |
| 28595999 |
Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by a marked decrease in expression of several nuclear envelope-associated components (Lamin B1, Lamin A/C, Sun1, Nesprin-3, Plectin) compared with controls. Furthermore, chromatin immunoprecipitation-quantitative PCR assay showed enrichment of p63 on Sun1, Syne3, and Plec promoters, suggesting them as p63 targets. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TP63 | up-regulates quantity by expression 
transcriptional regulation
|
PERP |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255136 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21965674 |
SATB2 attenuates p63-mediated gene expression of perp (p53 apoptosis effector related to PMP-22), a critical downstream target gene during development, and specifically decreases p63 perp promoter binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SATB2 | down-regulates activity
binding
|
TP63 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21965674 |
SATB2 attenuates p63-mediated gene expression of perp (p53 apoptosis effector related to PMP-22), a critical downstream target gene during development, and specifically decreases p63 perp promoter binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP63 | up-regulates quantity by expression
transcriptional regulation
|
PLEC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263279 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 28595999 |
Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by a marked decrease in expression of several nuclear envelope-associated components (Lamin B1, Lamin A/C, Sun1, Nesprin-3, Plectin) compared with controls. Furthermore, chromatin immunoprecipitation-quantitative PCR assay showed enrichment of p63 on Sun1, Syne3, and Plec promoters, suggesting them as p63 targets. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TP63 | up-regulates quantity by expression
transcriptional regulation
|
SYNE3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263280 |
|
|
Mus musculus |
Epidermal Stem Cell |
| pmid |
sentence |
| 28595999 |
Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by a marked decrease in expression of several nuclear envelope-associated components (Lamin B1, Lamin A/C, Sun1, Nesprin-3, Plectin) compared with controls. Furthermore, chromatin immunoprecipitation-quantitative PCR assay showed enrichment of p63 on Sun1, Syne3, and Plec promoters, suggesting them as p63 targets. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
TP63
- 
- 