| + |
FBXL15 | up-regulates activity 
binding
|
Cullin 1-RBX1-Skp1 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271910 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21572392 |
Here, we report that F-box and LRR domain-containing protein 15 (FBXL15), an F-box protein of the FBXL family, forms an Skp1-Cullin1-F-box protein-Roc1 (SCF)(FBXL15) ubiquitin ligase complex and targets Smurf1 for ubiquitination and proteasomal degradation. FBXL15, through its leucine-rich repeat domain, specifically recognizes the large subdomain within the N-lobe of the Smurf1 HECT domain and promotes the ubiquitination of Smurf1 on K355 and K357 within the WW-HECT linker region. In this way, FBXL15 positively regulates BMP signalling in mammalian cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXL15 | down-regulates quantity by destabilization 
binding
|
SMURF1 (isoform 2) |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271909 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21572392 |
Here, we report that F-box and LRR domain-containing protein 15 (FBXL15), an F-box protein of the FBXL family, forms an Skp1-Cullin1-F-box protein-Roc1 (SCF)(FBXL15) ubiquitin ligase complex and targets Smurf1 for ubiquitination and proteasomal degradation. FBXL15, through its leucine-rich repeat domain, specifically recognizes the large subdomain within the N-lobe of the Smurf1 HECT domain and promotes the ubiquitination of Smurf1 on K355 and K357 within the WW-HECT linker region. In this way, FBXL15 positively regulates BMP signalling in mammalian cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FBXL15
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