4.0
Summary
| Name |  TUT1View Modifications |
| Full Name | Speckle targeted PIP5K1A-regulated poly(A) polymerase |
| Synonyms | Star-PAP, EC 2.7.7.19, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase, EC 2.7.7.52 | RBM21 |
| Primary ID | Q9H6E5 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK1A1 | up-regulates activity 
phosphorylation
|
TUT1 | 0.267 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KLHL7 | down-regulates quantity by destabilization 
binding
|
TUT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TUT1 | up-regulates 
|
mRNA_polyadenylation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHKA | up-regulates activity
phosphorylation
|
TUT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCD | up-regulates activity
phosphorylation
|
TUT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
TUT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |