| + |
KAT5 | up-regulates activity 
acetylation
|
CHKA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267648 |
Lys247 |
MPFNKEPkWLFGTME |
Homo sapiens |
|
| pmid |
sentence |
| 34929314 |
Glucose deprivation induces the binding of choline kinase α2 (CHKα2) to lipid droplets, followed by a continuous PTMs to promote lipolysis of lipid droplets, which are in turn mediated by AMPK-dependent CHKα2 Serine 279 phosphorylation and KAT5-dependent CHKα2 Lysine 247 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | up-regulates activity
phosphorylation
|
CHKA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267647 |
Ser279 |
KKLHKLLsYNLPLEL |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 34929314 |
Glucose deprivation induces the binding of choline kinase α2 (CHKα2) to lipid droplets, followed by a continuous PTMs to promote lipolysis of lipid droplets, which are in turn mediated by AMPK-dependent CHKα2 Serine 279 phosphorylation and KAT5-dependent CHKα2 Lysine 247 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
CHKA |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266351 |
Tyr197 |
RSLGPKLyGIFPQGR |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21822308 |
We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-dependent manner on Y197 and Y333. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266350 |
Tyr333 |
LMLIDFEySSYNYRG |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21822308 |
We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-dependent manner on Y197 and Y333. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization 
phosphorylation
|
PLIN2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267649 |
Tyr232 |
TKLHSRAyQQALSRV |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 34929314 |
In addition, as a protein kinase, CHKalpha2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
PLIN3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267650 |
Tyr251 |
ERLRQHAyEHSLGKL |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 34929314 |
In addition, as a protein kinase, CHKα2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | up-regulates activity
binding
|
EGFR |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266352 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21822308 |
We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-dependent manner on Y197 and Y333. CHKA is required for maximum EGF-dependent cell growth in mammary epithelium-derived cell lines |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity
chemical modification
|
choline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275637 |
|
|
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes |
|
| Publications: |
1 |
| + |
CHKA | up-regulates quantity
chemical modification
|
choline phosphate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275636 |
|
|
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes |
|
| Publications: |
1 |
3.0
CHKA
- 
- 