Summary

Name RANBP3
Full Name Ran-binding protein 3
Synonyms RanBP3
Primary ID Q9H6Z4
Links - -
Type protein
Relations 12
Function Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ RPS6KA1 img/unknown.png phosphorylation RANBP3 0.325
Publications: 1 Organism: Homo Sapiens
+ AKT img/unknown.png phosphorylation RANBP3 0.2
Publications: 1 Organism: Homo Sapiens
+ RPS6K img/unknown.png phosphorylation RANBP3 0.2
Publications: 1 Organism: Homo Sapiens
+ AKT1 img/unknown.png phosphorylation RANBP3 0.367
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates quantity img/direct-activation.png phosphorylation RANBP3 0.335
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates quantity img/direct-activation.png phosphorylation RANBP3 0.325
Publications: 1 Organism: Homo Sapiens
+ AKTup-regulates quantity img/direct-activation.png phosphorylation RANBP3 0.2
Publications: 1 Organism: Homo Sapiens
+ RANBP3down-regulates activity img/direct_inhibition.png relocalization SMAD3 0.398
Publications: 2 Organism: Homo Sapiens
+ RANBP3down-regulates activity img/direct_inhibition.png relocalization SMAD2 0.447
Publications: 2 Organism: Homo Sapiens
+ RANBP3down-regulates img/direct_inhibition.png relocalization SMAD3 0.398
Publications: 1 Organism: Homo Sapiens