| + |
CSNK2A1 | up-regulates activity 
phosphorylation
|
CERS4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273981 |
Ser342 |
QMEKDIRsDVEESDS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26887952 |
Most of the phosphorylated residues conformed to a consensus motif for phosphorylation by casein kinase 2 (CK2), and treatment of cells with the CK2-specific inhibitor CX-4945 lowered the phosphorylation levels of CERS2, -4, -5, and -6. Phosphorylation of CERS2 was especially important for its catalytic activity, acting mainly by increasing itsVmaxvalue. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273983 |
Ser347 |
IRSDVEEsDSSEEAA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26887952 |
Most of the phosphorylated residues conformed to a consensus motif for phosphorylation by casein kinase 2 (CK2), and treatment of cells with the CK2-specific inhibitor CX-4945 lowered the phosphorylation levels of CERS2, -4, -5, and -6. Phosphorylation of CERS2 was especially important for its catalytic activity, acting mainly by increasing itsVmaxvalue. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273984 |
Ser349 |
SDVEESDsSEEAAAA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26887952 |
Most of the phosphorylated residues conformed to a consensus motif for phosphorylation by casein kinase 2 (CK2), and treatment of cells with the CK2-specific inhibitor CX-4945 lowered the phosphorylation levels of CERS2, -4, -5, and -6. Phosphorylation of CERS2 was especially important for its catalytic activity, acting mainly by increasing itsVmaxvalue. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273982 |
Ser350 |
DVEESDSsEEAAAAQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26887952 |
Most of the phosphorylated residues conformed to a consensus motif for phosphorylation by casein kinase 2 (CK2), and treatment of cells with the CK2-specific inhibitor CX-4945 lowered the phosphorylation levels of CERS2, -4, -5, and -6. Phosphorylation of CERS2 was especially important for its catalytic activity, acting mainly by increasing itsVmaxvalue. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CERS4 | up-regulates quantity
chemical modification
|
ceramide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26887952 |
Ceramides in mammals vary greatly in their acyl-chain composition: six different ceramide synthase isozymes (CERS1-6) that exhibit distinct substrate specificity and tissue distribution account for this diversity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CERS4
- 
- 