4.0
Summary
| Name |  CLSPNView Modifications |
| Full Name | Claspin |
| Synonyms | hClaspin |
| Primary ID | Q9HAW4 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK1 | down-regulates 
phosphorylation
|
CLSPN | 0.778 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PI4K2A | down-regulates
phosphorylation
|
CLSPN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHEK1 | up-regulates 
phosphorylation
|
CLSPN | 0.798 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXW11 | down-regulates
ubiquitination
|
CLSPN | 0.343 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLSPN | up-regulates
binding
|
CHEK1 | 0.798 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC7 | up-regulates activity
phosphorylation
|
CLSPN | 0.747 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP20 | up-regulates quantity by stabilization
deubiquitination
|
CLSPN | 0.507 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | APC-c | down-regulates quantity by destabilization
ubiquitination
|
CLSPN | 0.26 |
| Publications: | 1 | |||
| + | WDHD1 | up-regulates activity
binding
|
CLSPN | 0.393 |
| Publications: | 1 | Organism: | Homo Sapiens | |