Relation Results

Summary

Name NTN4
Full Name Netrin-4
Synonyms Beta-netrin, Hepar-derived netrin-like protein
Primary ID Q9HB63
Links - -
Type protein
Relations 3
Function May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Viewer

Type: Score: Layout: SPV 
0.6020.6010.546NTN4UNC5UNC5ANEO1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ NTN4up-regulates activity img/direct-activation.png binding UNC5 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-268184 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
+ NTN4up-regulates img/direct-activation.png binding UNC5A 0.601
Identifier Residue Sequence Organism Cell Line
SIGNOR-98483 Homo sapiens
pmid sentence
The unc5hs are axon guidance receptors that mediate netrin-1-dependent chemorepulsion, and dependence receptors that mediate netrin-1-independent apoptosis.
Publications: 1 Organism: Homo Sapiens
+ NTN4up-regulates activity img/direct-activation.png binding NEO1 0.546
Identifier Residue Sequence Organism Cell Line
SIGNOR-268170 Homo sapiens
pmid sentence
Experiments have demonstrated that Neogenin also mediates Netrin-1 attractive functions. Both DCC and Neogenin are type I transmembrane receptors that belong to the immunoglobulin superfamily proteins.
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
a simple tooltip