| + |
NTN1 | up-regulates activity 
binding
|
NEO1 |
0.819 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28245592 |
Experiments have demonstrated that Neogenin also mediates Netrin-1 attractive functions. Both DCC and Neogenin are type I transmembrane receptors that belong to the immunoglobulin superfamily proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Nervous System |
| Pathways: | Axon guidance |
| + |
Netrin | up-regulates activity
binding
|
NEO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268172 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21558366 |
In mammals, three secreted netrins, netrin 1, 3 and 4, and two membrane-tethered glycophosphatidylinositol (GPI)-linked (see Glossary, Box 1) netrins, netrin G1 and G2, have been identified. In mammals, receptors for the secreted netrins include deleted in colorectal cancer (DCC), the DCC paralogue neogenin, the UNC-5 homologues UNC5A-D, and Down syndrome cell adhesion molecule (DSCAM). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Nervous System |
| Pathways: | Axon guidance |
| + |
NEO1 | up-regulates 
|
Chemoattraction_of_axon |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268395 |
|
|
|
|
| pmid |
sentence |
| 17204444 |
Neogenin, a close relative of the axon guidance receptor Deleted in Colorectal Cancer (DCC), has been shown to be a receptor for members of the Netrin and Repulsive Guidance Molecule (RGM) families. While Netrin-1-Neogenin interactions result in a chemoattractive axon guidance response, the interaction between Neogenin and RGMa induces a chemorepulsive response. |
|
| Publications: |
1 |
| Pathways: | Axon guidance |
| + |
NTN4 | up-regulates activity
binding
|
NEO1 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268170 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28245592 |
Experiments have demonstrated that Neogenin also mediates Netrin-1 attractive functions. Both DCC and Neogenin are type I transmembrane receptors that belong to the immunoglobulin superfamily proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Nervous System |
| + |
NTN3 | up-regulates activity
binding
|
NEO1 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268171 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28245592 |
Experiments have demonstrated that Neogenin also mediates Netrin-1 attractive functions. Both DCC and Neogenin are type I transmembrane receptors that belong to the immunoglobulin superfamily proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Nervous System |
| + |
RGMA | down-regulates activity 
binding
|
NEO1 |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268388 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18485097 |
Netrin-1-neogenin interactions mediate chemoattractive axon guidance, while RGMa-neogenin interactions repel axons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Axon guidance |
3.0
NEO1
- 
- 