| + |
PKA | up-regulates activity 
phosphorylation
|
TRPV4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260885 |
Ser162 |
FDIVSRGsTADLDGL |
Homo sapiens |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276232 |
Ser162 |
FDIVSRGsTADLDGL |
in vitro |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276233 |
Ser189 |
DEEFREPsTGKTCLP |
in vitro |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260883 |
Ser189 |
DEEFREPsTGKTCLP |
Homo sapiens |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260881 |
Thr175 |
GLLPFLLtHKKRLTD |
Homo sapiens |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276231 |
Thr175 |
GLLPFLLtHKKRLTD |
in vitro |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens, In Vitro |
| + |
PKC | up-regulates activity
phosphorylation
|
TRPV4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276229 |
Ser162 |
FDIVSRGsTADLDGL |
in vitro |
|
| pmid |
sentence |
| 19661060 |
Activation of the TRPV4 ion channel is enhanced by phosphorylation. TRPV4 is phosphorylated in response to activation of PKC. We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276230 |
Ser189 |
DEEFREPsTGKTCLP |
in vitro |
|
| pmid |
sentence |
| 19661060 |
Activation of the TRPV4 ion channel is enhanced by phosphorylation. TRPV4 is phosphorylated in response to activation of PKC. We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276228 |
Thr175 |
GLLPFLLtHKKRLTD |
in vitro |
|
| pmid |
sentence |
| 19661060 |
Activation of the TRPV4 ion channel is enhanced by phosphorylation. TRPV4 is phosphorylated in response to activation of PKC. We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
PRKCA | up-regulates activity
phosphorylation
|
TRPV4 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260886 |
Ser162 |
FDIVSRGsTADLDGL |
Homo sapiens |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260884 |
Ser189 |
DEEFREPsTGKTCLP |
Homo sapiens |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260882 |
Thr175 |
GLLPFLLtHKKRLTD |
Homo sapiens |
|
| pmid |
sentence |
| 19661060 |
We conclude that the serine/threonine kinases PKC and PKA enhance activation of the TRPV4 ion channel by phosphorylation at specific sites and that phosphorylation depends on assembly of PKC and PKA by AKAP79 into a signaling complex with TRPV4. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SGK1 | up-regulates activity
phosphorylation
|
TRPV4 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279386 |
Ser824 |
LRRDRWSsVVPRVVE |
Homo sapiens |
|
| pmid |
sentence |
| 25972993 |
Recently, we identified that TRPV4 is also one of SGK1 substrate proteins (Fig. . , and the phosphorylation on serine 824 by SGK1 regulates the binding affinity to actin or tubulin [31].|Therefore, we propose the hypothesis that the SGK1 phosphorylation may enhance TRPV4 channel density in the plasma membrane through the dissociation from STIM1, similar with the regulation mechanism of GLUT4 or AQP2 by insulin or vasopressin, respectively , ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRPV4 | down-regulates quantity by repression 
transcriptional regulation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253095 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
TRPV4 negatively regulated the expression of PGC1α, UCP1, and cellular respiration. Additionally, it potently controlled the expression of multiple proinflammatory genes involved in the development of insulin resistance. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ITCH | down-regulates activity 
ubiquitination
|
TRPV4 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272625 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17110928 |
AIP4 ubiquitin ligase is involved in the ubiquitination of both TRPV4 and TRPC4.Ubiquitination of TRPV4 is dramatically increased by the HECT (homologous to E6-AP carboxyl terminus)-family ubiquitin ligase AIP4 without inducing degradation of this channel. Instead, AIP4 promotes the endocytosis of TRPV4 and decreases its amount at the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OS9 | up-regulates quantity by stabilization
binding
|
TRPV4 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261064 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17932042 |
Here we report that OS-9, a ubiquitously expressed endoplasmic reticulum (ER)-associated protein, interacts with the cytosolic N-terminal tail of TRPV4.Thus, OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation. Our data suggest that OS-9 functions as an auxiliary protein for TRPV4 maturation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK1016790A | up-regulates activity
binding
|
TRPV4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253094 |
|
|
|
|
| pmid |
sentence |
| 23021218 |
We next examined whether chemical activation of TRPV4 would have the opposite impact on these pathways. When added to 3T3-F442A adipocytes, the TRPV4 agonist GSK1016790A repressed the expression of mRNAs encoding Pgc1a, Ucp1, and Cox8b in a TRPV4-dependent manner (Fig- ure 2I). Taken together, these data strongly suggest that TRPV4 functions as a negative regulator of PGC1a and oxidative metabolism in white adipocytes. |
|
| Publications: |
1 |
| + |
TRPV4 | down-regulates quantity by repression
transcriptional regulation
|
UCP1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253096 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
TRPV4 negatively regulated the expression of PGC1α, UCP1, and cellular respiration. Additionally, it potently controlled the expression of multiple proinflammatory genes involved in the development of insulin resistance. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
TRPV4
- 
- 