Summary

Name ENY2
Full Name Transcription and mRNA export factor ENY2
Synonyms Enhancer of yellow 2 transcription factor homolog |
Primary ID Q9NPA8
Links - -
Type protein
Relations 1
Function Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding SAGA complex 0.574
Publications: 1 Organism: Homo Sapiens