Summary

Name PARD6A
Full Name Partitioning defective 6 homolog alpha
Synonyms PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax interaction protein 40, TIP-40 | PAR6A
Primary ID Q9NPB6
Links - -
Type protein
Relations 6
Function Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PARD6A 0.437
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.616
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PARD6/SMURF1 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PARD6A 0.625
Publications: 1 Organism: Homo Sapiens