Summary

Name UBE2T
Full Name Ubiquitin-conjugating enzyme E2 T
Synonyms Cell proliferation-inducing gene 50 protein, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T |
Primary ID Q9NPD8
Links - -
Type protein
Relations 4
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386).

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ Ub:E1 (UBA1 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2T 0.684
Publications: 1 Organism: Homo Sapiens
+ FANCLdown-regulates quantity img/direct_inhibition.png ubiquitination UBE2T
Publications: 1 Organism: Homo Sapiens
+ UBE2Tup-regulates activity img/direct-activation.png ubiquitination FANCL 0.899
Publications: 1 Organism: In Vitro
+ Ub:E1 (UBA6 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2T 0.47
Publications: 1 Organism: Homo Sapiens