3.0
Summary
| Name |  UBE2T
|
| Full Name | Ubiquitin-conjugating enzyme E2 T |
| Synonyms | Cell proliferation-inducing gene 50 protein, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T | |
| Primary ID | Q9NPD8 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | Ub:E1 (UBA1 substrate) | up-regulates activity 
ubiquitination
|
UBE2T | 0.682 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBE2T | up-regulates activity
ubiquitination
|
FANCL | 0.898 |
| Publications: | 1 | Organism: | In Vitro | |
| + | Ub:E1 (UBA6 substrate) | up-regulates activity
ubiquitination
|
UBE2T | 0.472 |
| Publications: | 1 | Organism: | Homo Sapiens | |