Summary

Name DIABLO
Full Name Diablo homolog, mitochondrial
Synonyms Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, Smac | SMAC
Primary ID Q9NR28
Links - -
Type protein
Relations 24
Pathways Death Receptor Signaling
Function Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png relocalization DIABLO 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization DIABLO 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BIRC5 0.43
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding XIAP 0.97
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates img/direct_inhibition.png binding DIABLO 0.43
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown DIABLO
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown DIABLO
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown DIABLO
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown CASP9
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates img/direct_inhibition.png binding XIAP
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity img/direct_inhibition.png binding BIRC2 0.91
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DIABLO 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding XIAP 0.97
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates activity img/direct_inhibition.png binding BIRC3 0.82
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding BIRC3 0.82
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization DIABLO
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIABLO 0.97
Publications: 1 Organism: In Vitro
Pathways:Death Receptor Signaling
+ down-regulates img/indirect_inhibition.png unknown DIABLO
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BIRC2 0.91
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding DIABLO 0.68
Publications: 1 Organism: Homo Sapiens