3.0
Death Receptor Signaling
Pathway ID: SIGNOR-DRView in NDEx
Description: The Death receptor (DR) signaling promotes apoptosis but, depending on the cellular context, it can also promote either prosurviaval and proinflammatory signaling pathways. There are six Tumor necrosis factor receptor (TNFR) family DR identified in human to date: Fas/CD-95, TNFR1, DR3, DR4, DR5, and DR6. These DR are activated by their respective ligands that also form a family of related molecules. The DRs initiate signaling by recruiting one of two platform adaptor molecules: FADD, that generally mediates apoptosis and/or TRADD, that engages both apoptotic and non-apoptotic signaling pathways. These adaptors in turn recruit distinct signaling complexes that mediates the downstream signaling events. This representation is focused on the signaling pathways downstream of DRs that directly promotes apoptosis, and describes pathways initiated by TNFR1 as the prototype of TRADD-mediated DR signaling (TNFR1, DR3, DR6) and Fas-activated pathways as the prototype of FADD-mediated DR signaling (FAS/CD-95, DR4, DR5).
Curated by: Anna Mattioni
Description: The Death receptor (DR) signaling promotes apoptosis but, depending on the cellular context, it can also promote either prosurviaval and proinflammatory signaling pathways. There are six Tumor necrosis factor receptor (TNFR) family DR identified in human to date: Fas/CD-95, TNFR1, DR3, DR4, DR5, and DR6. These DR are activated by their respective ligands that also form a family of related molecules. The DRs initiate signaling by recruiting one of two platform adaptor molecules: FADD, that generally mediates apoptosis and/or TRADD, that engages both apoptotic and non-apoptotic signaling pathways. These adaptors in turn recruit distinct signaling complexes that mediates the downstream signaling events. This representation is focused on the signaling pathways downstream of DRs that directly promotes apoptosis, and describes pathways initiated by TNFR1 as the prototype of TRADD-mediated DR signaling (TNFR1, DR3, DR6) and Fas-activated pathways as the prototype of FADD-mediated DR signaling (FAS/CD-95, DR4, DR5).
Curated by: Anna Mattioni
