| + |
MIB1 | up-regulates activity 
ubiquitination
|
DLL4 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16140393 |
Mib physically interacts with Delta and promotes its ubiquitination and internalization [66], which have been shown to up-regulate Notch activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
DLL4 | up-regulates activity
binding
|
NOTCH1 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209735 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 16140393 |
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112649 |
|
|
Homo sapiens |
Hematopoietic Cell |
| pmid |
sentence |
| 11739188 |
Expression analysis of known notch ligands suggests that dll4 is the only ligand that exhibits spatial and temporal expression consistent with the activation of notch1 and notch4 during vascular development. The identification of dll4 reveals a candidate ligand for notch receptors involved in blood vessel biology |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77973 |
|
|
Homo sapiens |
Hematopoietic Cell |
| pmid |
sentence |
| 10837024 |
Expression analysis of known notch ligands suggests that dll4 is the only ligand that exhibits spatial and temporal expression consistent with the activation of notch1 and notch4 during vascular development. The identification of dll4 reveals a candidate ligand for notch receptors involved in blood vessel biology |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
DLL4 | up-regulates activity
binding
|
PP2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209744 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 16140393 |
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLL4 | down-regulates quantity by repression 
transcriptional regulation
|
KDR |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178026 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18339870 |
Dll4 down-regulates vascular endothelial growth factor (vegf) receptor 2 and nrp1 expression and inhibits vegf function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VEGFA | up-regulates quantity by expression 
transcriptional regulation
|
DLL4 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196736 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22426001 |
Activation triggered by vegf-a (also known as vegf) has been shown to induce expression of thenotchligand dll4 in angiogenic vessels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
DLL4 | down-regulates quantity by repression
transcriptional regulation
|
NRP1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18339870 |
Dll4 down-regulates vascular endothelial growth factor (vegf)_ receptor_ 2 and nrp1 expression and inhibits vegf function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DLL4
- 
- 