Summary

Name ARHGEF4
Full Name Rho guanine nucleotide exchange factor 4
Synonyms APC-stimulated guanine nucleotide exchange factor 1, Asef, Asef1 | KIAA1112
Primary ID Q9NR80
Links - -
Type protein
Relations 3
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ARHGEF4 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.727
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.65
Publications: 1 Organism: Homo Sapiens