Summary

Name KCNQ5
Full Name Potassium voltage-gated channel subfamily KQT member 5
Synonyms KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv7.5 |
Primary ID Q9NR82
Links - -
Type protein
Relations 2
Function Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation KCNQ5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization potassium(1+) 0.8
Publications: 1 Organism: Homo Sapiens