| + |
KCNC3 | down-regulates quantity 
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11506885 |
Kv3 currents are activated specifically during action potential repolarization. Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCND3 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265657 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24762397 |
Kv4.3 belongs to voltage activated (Kv) K+ channel, mammalian Shal-related family. It is encoded by KCND3 gene and expressed in heart, brain and smooth muscle. Transient outward K+ current (I(to)) plays a crucial role in the early phase of cardiac action potential repolarization. Kv4.3 K(+) channel is an important component of I(to). The function and expression of Kv4.3 K(+) channel decrease in variety of heart diseases, especially in heart hypertrophy/heart failure. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
potassium(1+) | up-regulates 
|
Excitatory_synaptic_transmission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265590 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11506885 |
Kv3 currents are activated specifically during action potential repolarization. Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNQ3 | up-regulates quantity 
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19298256 |
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contribute to M-like currents in some locations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A5 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264398 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNC4 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11506885 |
Kv3 currents are activated specifically during action potential repolarization. Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNC1 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11506885 |
Kv3 currents are activated specifically during action potential repolarization. Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNS3 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269448 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10484328 |
We describe the cloning and characterization of the first human members, hKv9.1 and hKv9.3, of the electrically silent delayed-rectifying-like K+ channel subfamily. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
KCNQ1 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265981 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19298256 |
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contribute to M-like currents in some locations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A3 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNMA1 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269191 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31152168 |
The large-conductance Ca2+- and voltage-activated K+ (BK) channel is a tetramer consisting of four α-subunits encoded by the KCNMA1 gene on chromosome 10q22.3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269198 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31152168 |
The large-conductance Ca2+- and voltage-activated K+ (BK) channel is a tetramer consisting of four α-subunits encoded by the KCNMA1 gene on chromosome 10q22.3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KCNQ4 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19298256 |
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contribute to M-like currents in some locations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KATP channel | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28842488 |
ATP-sensitive K+ (KATP) channels, found throughout the body, are generated as octameric complexes consisting of four pore-forming Kir6.1 or Kir6.2 subunits with four regulatory sulfonylurea receptor (SUR1 or SUR2) subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNQ5 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19298256 |
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contribute to M-like currents in some locations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNS1 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269449 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10484328 |
We describe the cloning and characterization of the first human members, hKv9.1 and hKv9.3, of the electrically silent delayed-rectifying-like K+ channel subfamily. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
KCNE3 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11506885 |
Kv3 currents are activated specifically during action potential repolarization. Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNQ2 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265982 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19298256 |
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contribute to M-like currents in some locations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNC2 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11506885 |
Kv3 currents are activated specifically during action potential repolarization. Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A4 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264397 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNJ16 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24561201 |
KCNJ10 encodes Kir4.1, a member of the K+ channel family known as inwardly rectifying K+ (Kir) channels. Kir4.1 channels may comprise either Kir4.1 homomers or Kir4.1/Kir5.1 heteromers |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP1A3 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22797008 |
The sodium/potassium transporting ATPase subunit alpha-3 (AT1A3; syn.: sodium pump subunit alpha-3; E.C. 3.6.3.9; UniProtKB ID: Q6PIC6) belongs to the cation transport ATPase (P-type) 3.A.3 family catalyzing hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action generates the electrochemical gradient of sodium and potassium ions thus providing energy for active transport of various nutrients. Three sodium/potassium transporting ATPase isoforms are expressed in the brain but AT1A3 is detectable in neurons exclusively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A1 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264395 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LETM1 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262542 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29123128 |
Others have suggested that LETM1 plays an essential role in mitochondrial K+ homeostasis by mediating the mitochondrial K+/H+ exchange |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SLC24A2 | down-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNJ10 | up-regulates quantity
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24561201 |
KCNJ10 encodes Kir4.1, a member of the K+ channel family known as inwardly rectifying K+ (Kir) channels. Kir4.1 channels may comprise either Kir4.1 homomers or Kir4.1/Kir5.1 heteromers |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
potassium(1+)