Summary

Name OSTC
Full Name Oligosaccharyltransferase complex subunit OSTC
Synonyms Hydrophobic protein HSF-28 |
Primary ID Q9NRP0
Links - -
Type protein
Relations 1
Function Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

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Relations

Regulator Mechanism target score ℹ
+ OSTCform complex img/form-complex.png binding OST-A complex 0.564
Publications: 1 Organism: Homo Sapiens