| Name
|
 FIRRM
|
| Full Name |
FIGNL1-interacting regulator of recombination and mitosis |
| Synonyms |
FIDGETIN-like-1 interacting protein, FLIP, POLO1-associating protein | APOLO1, C1orf112 |
| Primary ID |
Q9NSG2 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (PubMed:34260926). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (PubMed:34260926). In complex with FIGL1 may regulate homologous recombination (PubMed:29608566). |
4.0
binding