Relation Results

Summary

Name UCKL1
Full Name Uridine-cytidine kinase-like 1
Synonyms EC 2.7.1.48 | URKL1
Primary ID Q9NWZ5
Links - -
Type protein
Relations 1
Function May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}.

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Type: Score: Layout: SPV 
0.588RNF19BUCKL1

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Relations
Regulator
Mechanism
target
score ℹ
+ RNF19Bdown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination UCKL1 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-271590 Homo sapiens Natural Killer Cell
pmid sentence
We demonstrated that both UbcH7 and UbcH8 bind to full-length NKLAM.  We demonstrated decreased protein expression and enhanced ubiquitination of URKL-1 in the presence of NKLAM. These data indicate that NKLAM is a RING finger protein that binds Ubcs and has as one of its substrates, URKL-1, thus defining this cytolytic protein as an E3 ubiquitin ligase.
Publications: 1 Organism: Homo Sapiens
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