| + |
CSNK2A1 | down-regulates 
phosphorylation
|
RRN3 |
0.206 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178939 |
Ser170 |
KEGDVDVsDSDDEDD |
Homo sapiens |
|
| pmid |
sentence |
| 18559419 |
Here we show that ck2 phosphorylates the transcription initiation factor tif-ia at serines 170 and 172 (ser170/172), and this phosphorylation triggers the release of tif-ia from pol i after transcription initiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178943 |
Ser172 |
GDVDVSDsDDEDDNL |
Homo sapiens |
|
| pmid |
sentence |
| 18559419 |
Here we show that ck2 phosphorylates the transcription initiation factor tif-ia at serines 170 and 172 (ser170/172), and this phosphorylation triggers the release of tif-ia from pol i after transcription initiation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CyclinE/CDK2 | up-regulates 
phosphorylation
|
RRN3 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216682 |
Ser44 |
LENDFFNsPPRKTVR |
Homo sapiens |
|
| pmid |
sentence |
| 15004009 |
Cdk2/cyclin e-mediated phosphorylation at ser 44 activates tif-ia |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates
phosphorylation
|
RRN3 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123231 |
Ser44 |
LENDFFNsPPRKTVR |
Homo sapiens |
|
| pmid |
sentence |
| 15004009 |
Cdk2/cyclin e-mediated phosphorylation at ser 44 activates tif-ia |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
RRN3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98980 |
Ser633 |
SFDTHFRsPSSSVGS |
Homo sapiens |
|
| pmid |
sentence |
| 12620228 |
Erk-dependent phosphorylation of the transcription initiation factor tif-ia is required for rna polymerase i transcription and cell growth. phosphopeptide mapping and mutational analysis reveals two serine residues (s633 and s649) that are phosphorylated by erk and rsk kinases. Replacement of s649 by alanine inactivates tif-ia, inhibits pre-rrna synthesis, and retards cell growth. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98984 |
Ser649 |
PVLYMQPsPL |
Homo sapiens |
|
| pmid |
sentence |
| 12620228 |
Erk-dependent phosphorylation of the transcription initiation factor tif-ia is required for rna polymerase i transcription and cell growth. phosphopeptide mapping and mutational analysis reveals two serine residues (s633 and s649) that are phosphorylated by erk and rsk kinases. Replacement of s649 by alanine inactivates tif-ia, inhibits pre-rrna synthesis, and retards cell growth. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | down-regulates
phosphorylation
|
RRN3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188403 |
Ser635 |
DTHFRSPsSSVGSPP |
Homo sapiens |
|
| pmid |
sentence |
| 19815529 |
We show that ampk down-regulates rrna synthesis under glucose restriction by phosphorylating the rna polymerase i (pol i)-associated transcription factor tif-ia at a single serine residue (ser-635). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates
phosphorylation
|
RRN3 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216592 |
Ser635 |
DTHFRSPsSSVGSPP |
Homo sapiens |
|
| pmid |
sentence |
| 19815529 |
We show that ampk down-regulates rrna synthesis under glucose restriction by phosphorylating the rna polymerase i (pol i)-associated transcription factor tif-ia at a single serine residue (ser-635). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK9 | down-regulates
phosphorylation
|
RRN3 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134878 |
Thr200 |
IARYVPStPWFLMPI |
Homo sapiens |
|
| pmid |
sentence |
| 15805466 |
Inactivation is due to phosphorylation of tif-ia by c-jun n-terminal kinase (jnk) at a single threonine residue (thr 200). Phosphorylation at thr 200 impairs the interaction of tif-ia with pol i and the tbp-containing factor tif-ib/sl1, thereby abrogating initiation complex formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RRN3 | up-regulates activity
relocalization
|
SL1 complex |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269647 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11250903 |
HRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters|We conclude that hRRN3 functions to recruit initiation-competent Pol I to rRNA gene promoters. The essential role for hRRN3 in linking Pol I to SL1 suggests a mechanism for growth control of Pol I transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
RRN3 | up-regulates activity
relocalization
|
RNA Polymerase I |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269648 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11250903 |
HRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters|We conclude that hRRN3 functions to recruit initiation-competent Pol I to rRNA gene promoters. The essential role for hRRN3 in linking Pol I to SL1 suggests a mechanism for growth control of Pol I transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
3.0
RRN3
- 
- 