+ |
PDP1 | up-regulates activity
dephosphorylation
|
PDHA1 |
0.72 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252055 |
Ser232 |
NRYGMGTsVERAAAS |
in vitro |
|
pmid |
sentence |
7782287 |
Sites 1, 2, and 3 were dephosphorylated either individually or in the presence of the other sites by the phospho-E1-phosphatase resulting in complete reactivation of the E1. The rates of dephosphorylation and reactivation were similar for sites 1, 2, and 3, indicating a random dephosphorylation mechanism |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252054 |
Ser293 |
TYRYHGHsMSDPGVS |
in vitro |
|
pmid |
sentence |
7782287 |
Sites 1, 2, and 3 were dephosphorylated either individually or in the presence of the other sites by the phospho-E1-phosphatase resulting in complete reactivation of the E1. The rates of dephosphorylation and reactivation were similar for sites 1, 2, and 3, indicating a random dephosphorylation mechanism |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252056 |
Ser300 |
SMSDPGVsYRTREEI |
in vitro |
|
pmid |
sentence |
7782287 |
Sites 1, 2, and 3 were dephosphorylated either individually or in the presence of the other sites by the phospho-E1-phosphatase resulting in complete reactivation of the E1. The rates of dephosphorylation and reactivation were similar for sites 1, 2, and 3, indicating a random dephosphorylation mechanism |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251664 |
|
|
Homo sapiens |
|
pmid |
sentence |
20208177 |
Pyruvate dehydrogenase phosphatase (PDP) is a mitochondrial serine phosphatase that activates phosphorylated pyruvate dehydrogenase complex by dephosphorylation |
|
Publications: |
4 |
Organism: |
In Vitro, Homo Sapiens |
+ |
ACAT1 | down-regulates activity
acetylation
|
PDP1 |
0.345 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267635 |
|
|
|
|
pmid |
sentence |
34289383 |
We previously reported that the mitochondrial fraction of FLT3 activates acetyl-CoA acetyltransferase ACAT1 in mitochondria via Y407 phosphorylation to acetylate and inhibit mitochondrial pyruvate dehydrogenase A (PDHA) and PDH phosphatase 1 (PDP1) |
|
Publications: |
1 |
+ |
PDP1 | down-regulates
dephosphorylation
|
SMAD1 |
0.246 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-144876 |
|
|
Homo sapiens |
|
pmid |
sentence |
16510868 |
We show that the mammalian pdps are important in dephosphorylation of bmp-activated smad1 but not tgf-beta-activated smad2 or smad3. Thus, pdps specifically inactivate smads in the bmp/dpp pathway. [...] These observations suggest that pdp1 and pdp2 are important for dephosphorylation of smad1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |