| + |
DHCR7 | down-regulates quantity 
chemical modification
|
cholesta-5,7-dien-3beta-ol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9634533 |
In cholesterol biosynthesis, 7-DHC is converted to cholesterol by the enzyme sterol D7 -reductase. This NADPH-dependent enzyme catalyzes the reduction of the D7 -diene bond in 7-DHC, to form cholesterol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DHCR24 | up-regulates activity 
binding
|
DHCR7 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267249 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 25637936 |
DHCR7 coimmunoprecipitates DHCR24. Overexpression of functional DHCR24 increases DHCR7 activity. Because knockdown of DHCR24 has no effect on DHCR7 mRNA (Fig. 3A), this implies that this phenomenon is occurring posttranscriptionally. Thus, the interaction between the two terminal steps of cholesterol synthesis appears to have functional consequences. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
DHCR7 | up-regulates quantity
chemical modification
|
cholesterol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9634533 |
In cholesterol biosynthesis, 7-DHC is converted to cholesterol by the enzyme sterol D7 -reductase. This NADPH-dependent enzyme catalyzes the reduction of the D7 -diene bond in 7-DHC, to form cholesterol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DHCR7
- 
- 