3.0
Summary
| Name |  DKK3
|
| Full Name | Dickkopf-related protein 3 |
| Synonyms | Dickkopf-3, Dkk-3, hDkk-3 | REIC |
| Primary ID | Q9UBP4 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
transcriptional regulation