Summary

Name MALT1
Full Name Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms MALT lymphoma-associated translocation, Paracaspase | MLT
Primary ID Q9UDY8
Links - -
Type protein
Relations 4
Function Protease that enhances BCL10-induced activation of NF-kappa-B by mediating its cleavage (PubMed:11262391, PubMed:18264101). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). Also has ubiquitin ligase activity

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding MALT1 0.796
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png polyubiquitination MALT1 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TAB2 0.591
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination MALT1 0.745
Publications: 1 Organism: Homo Sapiens