Summary

Name TAB2
Full Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Synonyms Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2 | KIAA0733, MAP3K7IP2
Primary ID Q9NYJ8
Links - -
Type protein
Relations 10
Pathways IL1 Signaling , NF-KB Canonical, P38 Signaling and Myogenesis, Satellite: IL1
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

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Relations

Regulator Mechanism target score ℹ
+ TAB2up-regulates activity img/direct-activation.png binding MAP3K7 0.934
Publications: 3 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical, P38 Signaling and Myogenesis
+ MALT1up-regulates img/direct-activation.png binding TAB2 0.59
Publications: 1 Organism: Homo Sapiens
+ RIPK1up-regulates activity img/direct-activation.png binding TAB2 0.858
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Canonical, P38 Signaling and Myogenesis
+ SMAD7up-regulates img/direct-activation.png binding TAB2 0.55
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ TAB2up-regulates img/direct-activation.png binding JNK 0.426
Publications: 1 Organism: Homo Sapiens
+ TAB2up-regulates img/direct-activation.png binding p38 0.558
Publications: 1 Organism: Homo Sapiens
+ TRAF6up-regulates activity img/direct-activation.png binding TAB2 0.931
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical