Relation Results

Summary

Name CNOT8
Full Name CCR4-NOT transcription complex subunit 8
Synonyms CAF1-like protein, CALIFp, CAF2, CCR4-associated factor 8, Caf1b | CALIF, POP2
Primary ID Q9UFF9
Links - -
Type protein
Relations 1
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catal ...
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Type: Score: Layout: SPV 
0.79CNOT8CCR4-NOT complex

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+ CNOT8form complex img/form-complex.png binding CCR4-NOT complex 0.79
Identifier Residue Sequence Organism Cell Line
SIGNOR-268310 Homo sapiens
pmid sentence
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules.
Publications: 1 Organism: Homo Sapiens
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