Summary

Name PARP2
Full Name Poly [ADP-ribose] polymerase 2
Synonyms PARP-2, hPARP-2, ADP-ribosyltransferase diphtheria toxin-like 2, ARTD2, NAD(+) ADP-ribosyltransferase 2, ADPRT-2, Poly[ADP-ribose] synthase 2, pADPRT-2 | ADPRT2, ADPRTL2
Primary ID Q9UGN5
Links - -
Type protein
Relations 6
Inhibitors olaparib; A-966492; veliparib; 1038915-60-4
Function Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:32028527, PubMed:32939087). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins

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Relations

Regulator Mechanism target score ℹ
+ olaparibdown-regulates img/direct_inhibition.png chemical inhibition PARP2 0.8
Publications: 1 Organism: Homo Sapiens
+ XRCC1up-regulates activity img/direct-activation.png binding PARP2 0.581
Publications: 1 Organism: Homo Sapiens
+ DNA_damageup-regulates img/indirect-activation.png PARP2 0.7
Publications: 1 Organism: Homo Sapiens
+ A-966492down-regulates img/direct_inhibition.png chemical inhibition PARP2 0.8
Publications: 1 Organism: Homo Sapiens
+ veliparibdown-regulates img/direct_inhibition.png chemical inhibition PARP2 0.8
Publications: 1 Organism: Homo Sapiens
+ 1038915-60-4down-regulates img/direct_inhibition.png chemical inhibition PARP2 0.8
Publications: 1 Organism: Homo Sapiens