Summary

Name NDOR1
Full Name NADPH-dependent diflavin oxidoreductase 1
Synonyms NADPH-dependent FMN and FAD-containing oxidoreductase, Novel reductase 1 | NR1
Primary ID Q9UHB4
Links - -
Type protein
Relations 1
Function NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:15900210, PubMed:20802492, PubMed:23596212, PubMed:28648056). Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:20802492, PubMed:23596212, PubMed:28648056). In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:20802492, PubMed:23596212). It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938).

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Relations

Regulator Mechanism target score ℹ
+ NDOR1form complex img/form-complex.png binding Anamorsin-NDOR1 complex 0.898
Publications: 1 Organism: Homo Sapiens