| + |
CSNK2A1 | down-regulates quantity by destabilization 
phosphorylation
|
IP6K2 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273624 |
Ser347 |
RPEVVLDsDAEDLED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21262846 |
CK2 physiologically phosphorylates IP6K2 at amino acid residues S347 and S356 contained within a PEST sequence, a consensus site for ubiquitination. HCT116 cells depleted of IP6K2 are resistant to cell death elicited by CK2 inhibitors. CK2 phosphorylation at the degradation motif of IP6K2 enhances its ubiquitination and subsequent degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273625 |
Ser356 |
AEDLEDLsEESADES |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21262846 |
CK2 physiologically phosphorylates IP6K2 at amino acid residues S347 and S356 contained within a PEST sequence, a consensus site for ubiquitination. HCT116 cells depleted of IP6K2 are resistant to cell death elicited by CK2 inhibitors. CK2 phosphorylation at the degradation motif of IP6K2 enhances its ubiquitination and subsequent degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
IP6K2
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