3.0
Summary
| Name |  FBXL7View Modifications |
| Full Name | F-box/LRR-repeat protein 7 |
| Synonyms | F-box and leucine-rich repeat protein 7, F-box protein FBL6/FBL7 | FBL6, FBL7, KIAA0840 |
| Primary ID | Q9UJT9 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization 
polyubiquitination
|
FBXL7 | 0.61 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FBXL18 | down-regulates quantity by destabilization
binding
|
FBXL7 | 0.636 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FBXL7 | down-regulates quantity by destabilization
binding
|
BIRC5 | 0.31 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FBXL7 | up-regulates activity 
binding
|
Cullin 1-RBX1-Skp1 | 0.61 |
| Publications: | 1 | Organism: | Mus Musculus | |