| + |
TNIK | up-regulates activity 
phosphorylation
|
NF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278388 |
Ser13 |
ASRMSFSsLKRKQPK |
Homo sapiens |
|
| pmid |
sentence |
| 33495197 |
Consistently with TNIK modulating Merlin, we also observed reduced YAP levels following TNIK knockdown in LK2 and NCI-H520 cells (Supplementary Fig. S7B).|Using in vitro kinase assays followed by phosphopeptide mapping, and mass spectrometry analysis on Merlin isolated from cells co-expressing TNIK and Merlin, we determined that TNIK could phosphorylate Merlin at S13, T272, S315, and T576 (Fig. 4B, Supplementary Fig. S4D, and Supplementary Table S3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278387 |
Ser315 |
MRRRKADsLEVQQMK |
Homo sapiens |
|
| pmid |
sentence |
| 33495197 |
Consistently with TNIK modulating Merlin, we also observed reduced YAP levels following TNIK knockdown in LK2 and NCI-H520 cells (Supplementary Fig. S7B).|Using in vitro kinase assays followed by phosphopeptide mapping, and mass spectrometry analysis on Merlin isolated from cells co-expressing TNIK and Merlin, we determined that TNIK could phosphorylate Merlin at S13, T272, S315, and T576 (Fig. 4B, Supplementary Fig. S4D, and Supplementary Table S3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278386 |
Thr272 |
SYSDKEFtIKPLDKK |
Homo sapiens |
|
| pmid |
sentence |
| 33495197 |
Consistently with TNIK modulating Merlin, we also observed reduced YAP levels following TNIK knockdown in LK2 and NCI-H520 cells (Supplementary Fig. S7B).|Using in vitro kinase assays followed by phosphopeptide mapping, and mass spectrometry analysis on Merlin isolated from cells co-expressing TNIK and Merlin, we determined that TNIK could phosphorylate Merlin at S13, T272, S315, and T576 (Fig. 4B, Supplementary Fig. S4D, and Supplementary Table S3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278385 |
Thr576 |
GGSSKHNtIKKLTLQ |
Homo sapiens |
|
| pmid |
sentence |
| 33495197 |
Consistently with TNIK modulating Merlin, we also observed reduced YAP levels following TNIK knockdown in LK2 and NCI-H520 cells (Supplementary Fig. S7B).|Using in vitro kinase assays followed by phosphopeptide mapping, and mass spectrometry analysis on Merlin isolated from cells co-expressing TNIK and Merlin, we determined that TNIK could phosphorylate Merlin at S13, T272, S315, and T576 (Fig. 4B, Supplementary Fig. S4D, and Supplementary Table S3). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
TNIK | up-regulates
phosphorylation
|
TCF7L2 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165946 |
Ser177 |
QALKDARsPSPAHIV |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 20530691 |
Here, we report that tnik is an activating kinase for tcf4 and essential for colorectal cancer growth. Tnik, but not its catalytically inactive mutant, phosphorylated the conserved serine 154 residue of tcf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNIK | down-regulates activity 
phosphorylation
|
SMAD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276334 |
Thr322 |
SNVNRNStIENTRRH |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 21690388 |
Msn kinases directly phosphorylate α-helix 1 of Smad. we have identified Misshapen (Msn) and the mammalian orthologs TNIK, MINK1, and MAP4K4 as the kinases responsible for α-helix 1 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TNIK
- 
- 