3.0
Summary
| Name |  TLK1View Modifications |
| Full Name | Serine/threonine-protein kinase tousled-like 1 |
| Synonyms | PKU-beta, Tousled-like kinase 1 | KIAA0137 |
| Primary ID | Q9UKI8 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TLK1 | up-regulates activity 
phosphorylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | TLK1 |
phosphorylation
|
RAD9A | 0.468 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TLK1 | up-regulates
phosphorylation
|
RAD9A | 0.468 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHEK1 | down-regulates 
phosphorylation
|
TLK1 | 0.445 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TLK1 | up-regulates activity
phosphorylation
|
NEK1 | 0.298 |
| Publications: | 1 | |||
| + | TLK1 | up-regulates activity
phosphorylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |