| + |
TLK1 | up-regulates activity 
phosphorylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107037 |
Ser11 |
TKQTARKsTGGKAPR |
in vitro |
|
| pmid |
sentence |
| 11314006 |
Purified tlk1b phosphorylated histone h3 at s(10) with high specificity both in a mix of core histones and in isolated chromatin, suggesting that histone h3 is a physiological substrate for tlk1b. Phosphorylation of H3 has been linked to the activation of the immediate-early genes upon mitogenic stimulation, and to chromatin condensation during mitotic/meiotic events. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
TLK1 | up-regulates activity
phosphorylation
|
MAPKAPK5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276745 |
Ser160 |
NLLFKDNsLDAPVKL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35064619 |
We established that TLK1 phosphorylates MK5 on three residues (S160, S354 and S386), resulting in MK5 activation, and additionally, mobility shifts of MK5 also supported its phosphorylation by TLK1 in transfected HEK 293 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276746 |
Ser354 |
VSLKPLHsVNNPILR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35064619 |
We established that TLK1 phosphorylates MK5 on three residues (S160, S354 and S386), resulting in MK5 activation, and additionally, mobility shifts of MK5 also supported its phosphorylation by TLK1 in transfected HEK 293 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276747 |
Ser386 |
HENGAEDsNVALEKL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35064619 |
We established that TLK1 phosphorylates MK5 on three residues (S160, S354 and S386), resulting in MK5 activation, and additionally, mobility shifts of MK5 also supported its phosphorylation by TLK1 in transfected HEK 293 cells. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
TLK1 | up-regulates
phosphorylation
|
RAD9A |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181748 |
Ser328 |
VLPSISLsPGPQPPK |
Homo sapiens |
|
| pmid |
sentence |
| 18940270 |
Tlk1b phosphorylates hrad9 at s328 after the induction of dsb, occupancy of rad9 adjacent to the break increased during repair while that of asf1 decreased, and the effect was more pronounced in tlk1b-overexpressing cells. We propose that following genotoxic stress, tlk1/1b is first recruited to the dsb in a complex with rad9. It then exchanges with asf1 to promote nucleosomes eviction at the dsb and access of the repair machinery to unencumbered dna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLK1 |
phosphorylation
|
RAD9A |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203499 |
Ser328 |
VLPSISLsPGPQPPK |
Homo sapiens |
|
| pmid |
sentence |
| 24376897 |
Here we show that rad9 is phosphorylated in a tlk-dependent manner in vitro and in vivo, and that t355 within the c-terminal tail is the primary targeted residue. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203503 |
Thr355 |
EPSTVPGtPPPKKFR |
Homo sapiens |
|
| pmid |
sentence |
| 24376897 |
Here we show that rad9 is phosphorylated in a tlk-dependent manner in vitro and in vivo, and that t355 within the c-terminal tail is the primary targeted residue. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHEK1 | down-regulates 
phosphorylation
|
TLK1 |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99653 |
Ser743 |
PHMRRSNsSGNLHMA |
Homo sapiens |
|
| pmid |
sentence |
| 12660173 |
Chk1 phosphorylates tlk1 on serine 695 (s695) these findings identify an unprecedented functional co- operation between atm and chk1 in propagation of a checkpoint response during s phase and suggest that, through transient inhibition of tlk kinases, the atm_chk1_tlk pathway may regulate processes involved in chromatin assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLK1 | up-regulates activity
phosphorylation
|
NEK1 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275840 |
Thr141 |
IFLTKDGtVQLGDFG |
|
|
| pmid |
sentence |
| 28426283 |
TLK1 phosphorylated NEK1 at T141, which lies in the kinase domain, and caused an increase in its activity. |
|
| Publications: |
1 |
| + |
TLK1 | up-regulates activity
phosphorylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265370 |
|
|
in vitro |
|
| pmid |
sentence |
| 11314006 |
Purified tlk1b phosphorylated histone h3 at s(10) with high specificity both in a mix of core histones and in isolated chromatin, suggesting that histone h3 is a physiological substrate for tlk1b. Phosphorylation of H3 has been linked to the activation of the immediate-early genes upon mitogenic stimulation, and to chromatin condensation during mitotic/meiotic events. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
TLK1
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