Summary

Name MAPKAPK5
Full Name MAP kinase-activated protein kinase 5
Synonyms MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAP-K5, MAPKAPK-5, MK-5, MK5, p38-regulated/activated protein kinase, PRAK | PRAK
Primary ID Q8IW41
Links - -
Type protein
Relations 14
Function Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DNAJB1 0.434
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK4 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TH 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.744
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EEF2K 0.304
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation KALRN 0.355
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLA2G4A 0.344
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK5 0.499
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK5 0.624
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK5 0.606
Publications: 1 Organism: Homo Sapiens