| + |
TIMELESS | up-regulates activity 
binding
|
CRY1 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268053 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 23418588 |
We performed a detailed molecular characterization of TIM interactions with the core clock protein CRY1 and the DNA damage signal transducer CHK1, and found that the N-terminus of TIM is required for association with both proteins, as well as for homodimerization. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Circadian clock |
| + |
TIMELESS | up-regulates activity
binding
|
CHEK1 |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268054 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 23418588 |
We performed a detailed molecular characterization of TIM interactions with the core clock protein CRY1 and the DNA damage signal transducer CHK1, and found that the N-terminus of TIM is required for association with both proteins, as well as for homodimerization. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
TIMELESS |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268052 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19805059 |
GR directly regulates transcription of circadian clock components in mouse and human primary MSCs. Per2, E4bp4, Per1, and Timeless rapidly respond to glucocorticoid stimulation. Primary glucocorticoid receptor (GR) target genes are those at which GR occupies a nearby genomic glucocorticoid response element (GRE) and regulates target gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
3.0
TIMELESS
- 
- 