Summary

Name COPS3
Full Name COP9 signalosome complex subunit 3
Synonyms SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3 | CSN3
Primary ID Q9UNS2
Links - -
Type protein
Relations 4
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding COPS3 0.414
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding COP9 signalosome variant 1 0.913
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding COP9 signalosome variant 2 0.913
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding SOS1 0.2
Publications: 1 Organism: Homo Sapiens