| + |
MAPK1 | down-regulates activity 
phosphorylation
|
SOS1 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235742 |
Ser1132 |
TLPHGPRsASVSSIS |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235933 |
Ser1167 |
ESAPAESsPSKIMSK |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235925 |
Ser1178 |
IMSKHLDsPPAIPPR |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236440 |
Ser1193 |
QPTSKAYsPRYSISD |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235929 |
Ser1197 |
KAYSPRYsISDRTSI |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10197981 |
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3 |
|
| Publications: |
6 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
SOS1 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43939 |
Ser1132 |
TLPHGPRsASVSSIS |
Homo sapiens |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five MAP kinase sites (S-1137, S-1167, S-1178, S-1193, and S-1197) on hSos1.Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43943 |
Ser1167 |
ESAPAESsPSKIMSK |
Homo sapiens |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43947 |
Ser1178 |
IMSKHLDsPPAIPPR |
Homo sapiens |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43951 |
Ser1193 |
QPTSKAYsPRYSISD |
Homo sapiens |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26338 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7478566 |
For example, inactivation of sos through phosphorylation by the downstream mapk |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates activity
phosphorylation
|
SOS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244580 |
Ser1132 |
TLPHGPRsASVSSIS |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244584 |
Ser1167 |
ESAPAESsPSKIMSK |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244588 |
Ser1197 |
KAYSPRYsISDRTSI |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20724475 |
ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process. |
|
| Publications: |
4 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| Tissue: |
Lung, Breast |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling |
| + |
ERK1/2 | down-regulates
phosphorylation
|
SOS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244743 |
Ser1178 |
IMSKHLDsPPAIPPR |
Homo sapiens |
|
| pmid |
sentence |
| 20724475 |
ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244747 |
Ser1193 |
QPTSKAYsPRYSISD |
Homo sapiens |
|
| pmid |
sentence |
| 20724475 |
ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling |
| + |
SOS1 | up-regulates 
guanine nucleotide exchange factor
|
KRAS |
0.82 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122075 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25624485 |
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25624485 |
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25624485 |
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141647 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25624485 |
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, COVID-19 Causal Network, Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Rhabdomyosarcoma, SARS-CoV MAPK PERTURBATION, Thyroid cancer |
| + |
SOS1 | up-regulates activity
guanine nucleotide exchange factor
|
NRAS |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110566 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11560935 |
Sos and Ras-GRF are two families of guanine nucleotide exchange factors that activate Ras proteins in cells. Sos proteins are ubiquitously expressed and are activated in response to cell-surface tyrosine kinase stimulation Sos1 and Ras-GRF1 activate the Ras proteins Ha-Ras, N-Ras, and Ki-Ras |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, IL6 Signaling, Inhibition of Apoptosis, Malignant Melanoma, Noonan syndrome |
| + |
GRB2 | up-regulates activity
relocalization
|
SOS1 |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235773 |
|
|
Mus musculus |
Embryonic Cell Line |
| pmid |
sentence |
| 23452850 |
Interaction domains of sos1/grb2 are finely tuned for cooperative control of embryonic stem cell fate. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236792 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 10570290 |
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39163 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8479541 |
Furthermore, our results indicate that the interaction domains of sos1 and grb2 have evolved so as to bind ligands not with maximal strength but with specificities and affinities that maintain cooperativity. Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. |
|
| Publications: |
3 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling |
| + |
PLCG1 | up-regulates
binding
|
SOS1 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80024 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10913276 |
We provide evidence that sos1, a p21ras-specific guanine nucleotide exchange factor, directly binds to the sh3 domain of plc-gamma1, and that the sh3 domain of plc-gamma1 is involved in sos1-mediated p21ras activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation, VEGF Signaling |
| + |
Gbeta | down-regulates
phosphorylation
|
SOS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8816480 |
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidic acid | up-regulates
chemical activation
|
SOS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17486115 |
Phosphatidic acid interacts with a defined site in the sos ph domain with high affinity and specificity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SHC1 | up-regulates
binding
|
SOS1 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236363 |
|
|
Mus musculus |
Swiss-3T3 Cell |
| pmid |
sentence |
| 17673906 |
TGF-beta-induced ShcA phosphorylation induces ShcA association with Grb2 and Sos, thereby initiating the well-characterised pathway linking receptor tyrosine kinases with Erk MAP kinases. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling, IL6 Signaling, Noonan syndrome, Thyroid cancer |
| + |
SPRY1 | down-regulates
binding
|
SOS1 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11585837 |
Taken together, these results establish mammalian sprouty proteins as important negative regulators of growth factor signaling and suggest that sprouty proteins act downstream of the grb2.Sos Complex to selectively uncouple growth factor signals from ras activation and the map kinase pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Noonan syndrome |
| + |
COPS3 | up-regulates quantity by stabilization
binding
|
SOS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256217 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30631038 |
Our observations characterizing the interaction between CSN3 and the Sos1 HD suggest that this domain not only functions regulating Sos-GEF autoinhibition but is also involved in other functional roles, such as the control of Sos protein stability and homeostasis by modulating the degradation and intracellular levels of Sos1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOS1 | up-regulates activity
guanine nucleotide exchange factor
|
HRAS |
0.886 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23132018 |
The enhancement of H-Ras GTP levels induced by oncogenic K-Ras was abrogated when the expression of endogenous Sos was suppressed, implicating Sos as an essential intermediate in the cross talk between oncogenic K-Ras and WT H-Ras. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59472 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23132018 |
The enhancement of H-Ras GTP levels induced by oncogenic K-Ras was abrogated when the expression of endogenous Sos was suppressed, implicating Sos as an essential intermediate in the cross talk between oncogenic K-Ras and WT H-Ras. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Integrin Signaling, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, RTKs in cancer, T cell activation, VEGF Signaling |
| + |
NCK1 | up-regulates
binding
|
SOS1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236321 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 7862111 |
We also found that nck binds directly to the guanine nucleotide exchange factor sos. / by binding to sos, nckmay bring sos to cell membrane where the ras protein is located. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Pathways: | EGFR Signaling, T cell activation |
3.0
SOS1
- 
- 